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To conduct this assay, the target lymphocytes arerendered incapable of replication, often by irradiation orby treatment with mitomycin C

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CYP3A4 and CYP3A5 are the most abundant(about 40% of the total) and metabolize about 40% of thetherapeutic agents that undergo oxidation. Treatment and outcome of periprosthetic ankle jointinfection: a single cohort center experience of 34 cases. Correlational studies have high external validity,meaning that a wide variety of variables can be generalized across large samples ofsubjects and replicated to include greater sample variance.

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This in turn causes DC to secrete TGF-? andmore Tregs are created (Marguti 2009).